[연구분야]

- 성체줄기세포를 이용한 인간 질환 치료

- 중간엽 줄기세포의 배양액 성분 (시크리톰), 세포외소포 (extracellular vesicle)

  의 면역학적, 재생의학적 활용 연구

- 유도만능줄기세포-유래 신경전구세포의 배양액 성분 활용에 의한 신경계 

  질환 치료

[최종학력]

- 뉴저지 주립대학교 (Rutgers University, the State University of New Jersey) 이학박사 (Ph.D)

[주요경력]

- 前 삼상생명과학연구소 선임연구원

- 前 연세대학교 의과대학 연구부교수

- 前 세브란스 병원 세포치료센터 부센터장

- 前 국제성모병원 세포치료센터 센터장

- 현재 가톨릭관동대학교 의생명과학과 교수

[학회 및 대외 활동]

- 국제줄기세포학회 정회원 (ISSCR)

- 한국 조직공학회 정회원, 부회장

- Tissue Engineering & Regenerative Medicine Associate Editor (부편집장)

[연구실적: 논문]

1.       Highly fluorescent conjugated polyelectrolyte for protein sensing and cell-compatible chemosensing applications. ACS Appl Mater Interface 2014, 6(5):3305-3311.

2.       Identification of pancreatic cancer-associated tumor antigen from HSP-enriched tumor lysate-pulsed human dendritic cells. Yonsei Med. J. 2014, 55(4):1014-1027

3.       Erythropoietic potential of CD34+ hematopoietic stem cells from human cord blood and G-CSF-mobilized peripheral blood. Biomed. Res. Int. 2014, 2014:435215.

4.       PSA-NCAM(+) neural precursor cells from human embryonic stem cells promote neural tissue integrity and behavioral performance in a rat stroke model. Stem Cell Rev. 2014, 10(6):761-71.

5.       Metabolomic approaches to the normal aging process. Metabolomics 2014, 10:1268-1292.

6.       CD31(+) cell transplantation promotes recovery from peripheral neuropathy. Mol Cell Neurosci. 2014, 62:60-7.

7.       Characteristics of circulating CD31(+) cells from patients with coronary artery disease. J Cell Mol Med. 2014,18(11):2321-30.

8.       PSA-NCAM-negative neural crest cells emerging during neural induction of pluripotent stem cells cause mesodermal tumors and unwanted grafts. Stem Cell Reports. 2015, 4(5):821-34.

9.       Progranulin and a five transmembrane domain-containing receptor-like protein are the key components in receptor activator of nuclear factor Kb (RANK)-dependent formation of multinucleated ssteoclasts. J Biol Chem. 2015, 290, 2042-2052.

10.    Flt3 ligand induces monocyte proliferation and enhances the function of monocyte-derived dendritic cells in vitro. J Cell Physiol. 2015, 230(8):1740-1749. 

11.    Adiponectin inhibits mouse mammary tumor growth and reduced tumor-induced hematopoiesis. Tissue Eng Reg Med 2015, 12(5):324-330.

12.    Globular adiponectin induced leukocytosis and mobilizes hematopoietic progenitor cells in mice. Tissue Eng Reg Med 2015, 12(6):449-456.

13.    Comparison of molecular profiles of human mesenchymal stem cells from different sources – bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med 2016, 37: 115-125 

14.    Extracellular vesicles as drug delivery vehicles for rheumatoid arthritis. Curr Stem Cell Res Ther 2016;11(4):329-42

15.    Microvesicles from brain-extract-treated mesenchymal stem cells improve neurological functions in a rat model of ischemic stroke. Sci Rep. 2016. 6:33038

16.    Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke. Oncotarget. 2016, 7(48):79131-79140

17.    Extracellular vesicles in neurodegenerative diseases; A double-edged sword. Tissue Eng. Reg. Med. 2017,14(6):667-678

18.    Development of a mouse IgA monoclonal antibody-based enzyme-linked immunosorbent sandwich assay for the analyses of RBP4. Sci Rep. 2018, 8(1):2578

19.    NaOH-HCl neutralized urine preparation for direct testing of uropathogens by Bruker MS. J Clin Lab Anal. 2018, 32(3): e22280.

20.    Pancreatic cancer cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro Anim Cells Syst (Seoul). 2018, 22(6):368-381.

21.    Reversion of in vivo fibrogenesis by novel chromone scaffolds. EBioMedicine. 2019, 39:484-496

22.    Exosomes as Therapeutic Vehicles for Cancer. Tissue Eng Regen Med. 2019, 16(3):213-223.

23.    Combination of human mesenchymal stem cells and repetitive transcranial magnetic stimulation enhances neurological recovery of 6-hydroxydopamine model of Parkinsonian’s disease. Tissue Eng Regen Med. 2020, 17(1):67-80.

24.    Eupatilin promotes cell death by calcium influx through ER-mitochondria axis with SERPINB11 inhibition in epithelial ovarian cancer. Cancers (Basel). 2020, 12(6):E1459.

25.    Extracellular Vesicles in Regenerative Medicine: Potentials and Challenges. Tissue Eng Regen Med. 2021, 18:479-484

26.    Generation of αMHC-EGFP knock-in in human pluripotent stem cell line, SNUe003-A-3 using CRISPR/Cas9-based gene targeting. Stem Cell Res. 2022, 61:102779.

27.    A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis. Int J Mol Sci. 2022, 23(12):6852.

28.    Conditioned Medium of Human Pluripotent Stem Cell-Derived Neural Precursor Cells Exerts Neurorestorative Effects against Ischemic Stroke Model. Int J Mol Sci. 2022, 14;23(14):7787.

29.    Establishment of TUBB3-mCherry knock-in human pluripotent stem cell line using CRISPR/Cas9 (SNUe003-A-4). Stem Cell Res. 2022, 69:103064.

30.    In vitro erythrocyte production using human-induced pluripotent stem cells: determining the best hematopoietic stem cell sources. Stem Cell Res Ther. 2023, 14(1):106.

31.    Blockade of stromal cell？derived factor？1 signaling disturbs the invasiveness of human extravillous trophoblast cells. Mol Cell Toxicol. 2023, In Press.

[특허]

1.       신경전구세포의 분비단백체를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물

2.       중간엽 줄기세포 유래 분비단백체를 포함하는 류마티스 관절염 치료용 약제학적 조성물 및 이를 이용한 치료 방법

3.       중간엽줄기세포 유래 미세소포체를 포함하는 발모촉진 또는 창상 치료용 약제학적 조성물

4.       줄기세포-유래 미세소포체를 유효성분으로 포함하는 신경질환 예방 또는 치료용 약제학적 조성물

[기술이전]

(1)  주식회사 에스바이오메딕스

-    신경전구세포의 분비단백체를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물

-     PSA-NCAM-양성 신경전구세포를 유효성분으로 포함하는 척수손상 치료용 조성물

(2)  주식회사 정진바이오사이언스

-     중간엽 줄기세포 유래 분비단백체를 포함하는 류마티스 관절염 치료용 약제학적 조성물 및 이를 이용한 치료 방법

[이메일]

hankim63@gmail.com; hansk@cku.ac.kr